Ultrasound imaging of ovarian follicles

The measurement of ovarian follicle size is often inaccurate, since the calculation is made considering the follicle as a two-dimensional structure and not a three-dimensional structure, which it is really.

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Reflection from ESHRE: Stem cells: Is it good to be naïve…?

The in vitro production of gametes from stem cells has elicited the interest of the professional and common public alike in recent years; what if we could re-create gametogenesis in a dish, and find out why it sometimes fails in our patients? What if we can make oogonia and spermatogonia in vitro, and test pollutants […]

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Training in the embryology lab: validation is the key

Rita Vassena

Scientific Director, Clinica EUGIN

ICSI, the introduction of a sperm into the cytoplasm of oocyte using a micropipette, is a widespread assisted technology of growing popularity worldwide; in Europe, ICSI was reportedly used in 271,711 ART cycles initiated during 2010, which corresponds to 68.40% of all ART cycles reported in the region. Much like other laboratory procedures, ICSI is […]

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Preconception genetic testing: towards preventive reproductive medicine

Dr. Amelia Rodriguez

Eugin Medical Director

Assisted reproduction technologies have undergone a major change in recent years. While in the past all our efforts were invariably aimed at obtaining better results in terms of the pregnancy rate, today, even though we can say that much remains to be done, we have results that can be described as better than good and […]

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Would you expect obstetrics complications in women with a high number of oocytes in IVF?

Prof. Antonio La Marca

Clinica Eugin Modena and Università degli Studi di Modena e Reggio Emilia

In the IVF world, the so called normal ovarian response to gonadotrophins stimulation is thought to be associated to the optimal reproductive success and several studies reported that the highest live birth rate is reached with the retrieval of 15 oocytes at pick up, as this number of oocytes ensures an adequate number of good […]

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Damage to the DNA occurs in human oocytes

Dr. Giovanni Coticchio

Biogenesi Scientific Coordinator

In animal models, especially in the cow and the mouse, resumption of the meiotic process and progression to a condition of meiotic maturity can be achieved in vitro very efficiently by fully grown-oocytes collected from graafian follicles, with rates of maturation exceeding 80-90%. On the contrary, in our species only 50-60% of immature oocytes attain […]

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Tailored education improves fertility knowledge and awareness

Désirée García

Fundación Eugin

Fertility knowledge and awareness are insufficient in reproductive-aged people around the world (Bunting 2013), particularly in relation to reproductive life span, risk factors for infertility, and limitations of assisted reproduction treatments. This is because to date, young people are not properly informed about fertility and preconceptional care, and then they are overoptimistic about their own […]

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Embryo aneuploidy and evolution: are we trying to make bad embryos?

Rita Vassena

Scientific Director, Clinica EUGIN

Those of us that work in ART know the frustrating experience of telling a woman that all her embryos are aneuploid, and not viable for transfer. Aneuploidy, i.e. the presence in the blastomeres of an embryo with an unbalanced chromosome complement, is extremely common in human embryos, and its frequency is associated with maternal age, […]

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Mitochondrial transfer: ready for the clinic?

Rita Vassena

Scientific Director, Clinica EUGIN

For all of us that are a bit oxidized on our cell biology days, I would remind you that the mitochondrion is an intracellular organelle found in almost all cells of an organism. Mitochondria are small, and their number within a cell is related with the cell function; as you all know, sperm cells contain […]

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To PGS or not to PGS?

Rita Vassena

Scientific Director, Clinica EUGIN

Preimplantation genetic screening (PGS) is the technique which involves the screen of the DNA of a preimplantation embryo in order to identify genetic alterations, mostly involving ploidy, in order to avoid transferring these embryos back into the mother uterus. After e few years in which PGS had lost interest within the medical community due to […]

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Embryos and implantation: The Good, the Bad, and the Ugly

Rita Vassena

Scientific Director, Clinica EUGIN

Last month we have closed the year with a piece about the role of the endometrium in selecting which embryo will implant, which generated a lot of interest, so much so that a few of you contacted us wanting to discuss more in detail the issue. Well, let’s listen to your interest and greet the […]

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Can we improve our empathic abilities?

Dr. Amelia Rodríguez

Medical Director, Clínica Eugin

Empathy, which is understood as the ability to put oneself in the place of another, to understand how they feel and adapt to it, is a skill that naturally has been associated not only with the practice of medicine, but to humans too. In the case of assisted reproduction in particular, where we are faced […]

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Who picks the embryo? The endometrium!

Rita Vassena

Scientific Director, Clinica EUGIN

Among reproductive specialist, the view of pregnancy has been classically “embryo centric”. Consistently, there is a widely held belief that the embryo is somewhat the main factor in deciding if implantation will take place, while the endometrium is often seen as a passive player. Sure, the endometrium needs to be prepared adequately, but it has […]

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Oxidative stress in semen: bad for reproduction?

Rita Vassena

Scientific Director, Clinica EUGIN

In the last few years, there have been a strong focus on the physiology of sperm, and andrology in general is going through a sort of golden age in Assisted Reproduction. One aspect that has received significant attention is the effect of Oxidative Stress (OS) on sperm health, and its possible relationship with reproductive outcomes. […]

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Tracking, witnessing, and the error-free laboratory

Rita Vassena

Scientific Director, Clinica EUGIN

As we mentioned in the last issue of this newsletter an imperative of modern medicine is the development of control and safety process in order to protect the patient from accidental events during a medical procedure. Moreover, the certification ISO 9001:2008 clearly indicates the need to identify the “product” of medical interventions, just as any […]

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Last Updated: November 2017